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Category:Publishing companies of India
Category:Publishing companies established in 2006
Category:2006 establishments in IndiaDurable response to cyclosporin and methotrexate therapy in two patients with severe systemic sclerosis.
In patients with systemic sclerosis and interstitial lung disease, pulmonary function tests show a substantial impairment of lung diffusion capacity. The possibility of an effect of immunosuppressive therapy on pulmonary function was investigated. Two patients with systemic sclerosis and pulmonary involvement were given cyclosporin (30 mg/kg body weight/d) and methotrexate (0.5 mg/kg body weight/wk) for 6 and 12 months, respectively. Pulmonary function tests and skin and muscle tests were carried out before and after the therapy. Both patients were improved with both lung diffusing capacity and muscular capacity. Long term therapy with cyclosporin and methotrexate could help in treating skin and muscle fibrosis. The lack of adverse effects and the good short and long term tolerance to therapy suggest that it could be considered as a treatment for pulmonary involvement in patients with systemic sclerosis.Role of neutrophils and macrophages during germination of Babesia bigemina merozoites.
A synchronized population of merozoites was obtained from infected erythrocytes of infected rodents. Macrophages and other leukocytes were removed from this population of merozoites and transferred to erythrocytes from normal rodents. After 1, 2, 3, 4, 5, 6, and 7 days of incubation in the presence of macrophages and other cells, the number of parasites attached to the erythrocyte membrane was determined. Compared with control merozoites incubated without cells, there was a significant decrease in the percentage of attached parasites after 3, 4, and 5 days of incubation in the presence of macrophages. Peritoneal macrophages lost their inhibitory activity after 2 days of incubation. The number of merozoites which attached to the cell membrane increased


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